Retiring Binding Affinity as a Predictor for Immune Response & Utilising Abundancy & Concentration as More Accurate Predictors for T-Cell Therapies
- Moving beyond traditional HLA–peptide binding affinity to focus on peptide abundance and cellular concentration as stronger indicators of immunogenicity
- Demonstrating that highly expressed and concentrated neoantigens correlate more reliably with robust T-cell activation and clinical response
- Incorporating quantitative peptide metrics into predictive algorithms to improve selection of optimal targets for personalised T-cell therapies