T-Cell Memory, Tumor Microenvironment, and Alloreactivity in Intracellular Neoantigen–Targeted Immunotherapy

• Emerging evidence highlights the importance of memory T-cell subsets, particularly stem-like and central memory populations, in sustaining long-term antitumor immunity.
• However, their function is frequently constrained by immunosuppressive cellular networks and metabolic barriers within the TME, including regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells.
• In parallel, advances in graft engineering and T-cell receptor editing provide strategies to mitigate alloreactivity while preserving graft-versus-tumor effects.

Speakers:

Thomas Böldicke

Senior Scientist

Helmholtz Centre for Infection Research